Rosette Spectroscopic Imaging for Whole-Brain Slab Metabolite Mapping at 7T: Acceleration Potential and Reproducibility.

ABSTRACT: Whole-brain proton magnetic resonance spectroscopic imaging (¹H-MRSI) is a non-invasive technique for assessing neurochemical distribution in the brain, offering valuable insights into brain functions and neural diseases. It greatly benefits from the improved SNR at ultrahigh field strengths (≥ 7T). However, ¹H-MRSI still faces several challenges, such as long acquisition time and severe signal contamination from water and lipids. In this study, 2D and 3D short TR/TE ¹H-FID-MRSI sequences using rosette trajectories were developed with nominal spatial resolutions of 4.48 × 4.48 mm² and 4.48 × 4.48 × 4.50 mm³, respectively. Water signals were suppressed using an optimized Five-variable-Angle-gaussian-pulses-with-ShorT-total-duration (FAS

SUBMITTER: Huang Z 

PROVIDER: S-EPMC11889463 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature