Sex-specific associations of sex hormone binding globulin and risk of bladder cancer.

ABSTRACT:

Background

Males have a three times higher risk of a diagnosis of bladder cancer (Bca) than females. Sex hormone-binding globulin (SHBG) may be associated with Bca risk. However, the sex-specific role of SHBG in Bca remains unclear. In this study, we aimed to determine the role of SHBG in Bca.

Methods

A sex-specific univariable Mendelian randomization (MR) analysis involving 369,426 men and 395,375 women was conducted to assess the causal relationship between SHBG and testosterone and Bca risk. Sensitivity analyses and multivariable MR were conducted to confirm the robustness of our results. Linkage disequilibrium score regression assessed the genetic correlation between these diseases influenced by heredity.

Results

Univariable MR results showed that one-SD elevated

SUBMITTER: Ou J 

PROVIDER: S-EPMC11889508 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature