Staged Screening Identifies People with Biomarkers Related to Neuronal Alpha-Synuclein Disease.

ABSTRACT:

Objective

Remote identification of individuals with severe hyposmia may enable scalable recruitment of participants with underlying alpha-synuclein aggregation. We evaluated the performance of a staged screening paradigm using remote smell testing to enrich for abnormal dopamine transporter single-photon emission computed tomography imaging (DAT-SPECT) and alpha-synuclein aggregation.

Methods

The Parkinson's Progression Markers Initiative (PPMI) recruited participants for the prodromal cohort who were 60-years and older without a Parkinson's disease diagnosis. Participants were invited to complete a University of Pennsylvania Smell Identification Test (UPSIT) independently through an online portal. Hyposmic participants were invited to complete DAT-SPECT, which determined el

SUBMITTER: Brown EG 

PROVIDER: S-EPMC11889527 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature