Atlas of Cerebrospinal Fluid Immune Cells Across Neurological Diseases.

ABSTRACT:

Objective

Cerebrospinal fluid (CSF) provides unique insights into the brain and neurological diseases. However, the potential of CSF flow cytometry applied on a large scale remains unknown.

Methods

We used data-driven approaches to analyze paired CSF and blood flow cytometry measurements from 8,790 patients (discovery cohort) and CSF only data from 3,201 patients (validation cohort) collected across neurological diseases in a real-world setting.

Results

In somatoform controls (n = 788), activation of T cells increased with age in both CSF and blood, whereas double negative blood T cells (CD3⁺CD4^-CD8^-) decreased with age. A machine learning model of CSF and blood immune cells defined immune age, which correlated strongly with true biolo

SUBMITTER: Heming M 

PROVIDER: S-EPMC11889529 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature