M2-like tumor-associated macrophages may promote tumor progression in malignant pleural mesothelioma.

ABSTRACT:

Introduction

Malignant pleural mesothelioma (MPM) is an aggressive malignancy with an unfavorable prognosis. Asbestos-activated macrophages may contribute to both oncogenesis and progression of MPM. This study aimed to clarify the biological and clinical significance of M2-like tumor-associated macrophages (TAMs) in MPM.

Methods

This retrospective study included 101 MPM patients who were diagnosed and started treatment between 1998 and 2010. The distribution of M2-like TAMs in the intratumoral and peritumoral regions was evaluated by immunohistochemistry using CD163 staining. Tumor proliferation was evaluated by Ki-67 staining.

Results

Intratumoral M2-like TAM density was significantly correlated with the pretreatment C-reactive protein level (r = 0.283, P = 0.004) an

SUBMITTER: Fukui T 

PROVIDER: S-EPMC11889561 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature