Altered neural signalling during reward anticipation in children and early adolescents with high psychotic-like experiences.

ABSTRACT:

Background

Schizophrenia is associated with abnormalities in neurodevelopmental processes. Furthermore, dysfunctional neural circuits involved in reward processing may be linked to the development of symptoms in schizophrenia and are predictive of long-term functional outcome. It is however unknown whether neural signatures of reward anticipation are detectable in children with high psychotic-like experiences.

Methods

Using data from the ABCD study 4.1, we defined a healthy control (N = 50) and a high psychotic-like experience (N = 50) group with a Prodromal Psychosis Syndrome (PPS) score > 3 and distress score > 6 at baseline (9-10 years) and 2nd year follow-up (11-12 years). While undergoing functional MR-imaging, all children completed the Monetary Incentive Delay task. U

SUBMITTER: Sen P 

PROVIDER: S-EPMC11889563 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature