Inflammatory markers and calcification of coronary arteries, aorta and cardiac valves: Findings from the atherosclerosis risk in communities study.

ABSTRACT:

Background

Inflammation plays an important role in the pathophysiology of atherosclerosis. However, inflammatory biomarkers have only been weakly associated with coronary artery calcium (CAC), a representative measure of subclinical atherosclerosis. Moreover, few studies explored extra-coronary calcium (ECC) in this context.

Aim

To characterize the association of two inflammatory markers, high-sensitivity C-reactive protein (hs-CRP) and galectin-3, at middle age with CAC and ECC at older age in a community-based cohort.

Methods

Cardiac CT was performed among 1,930 Atherosclerosis Risk in Communities (ARIC) study participants (age 73-95) without coronary heart disease at visit 7 (2018-19). We examined the associations of hs-CRP and galectin-3 measured (age 53-74 years)

SUBMITTER: Avula V 

PROVIDER: S-EPMC11889617 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature