Innovative 3D-printed porous tantalum cage with non-window design to accelerate spinal fusion: A proof-of-concept study.

ABSTRACT: An interbody fusion cage is crucial in spine fusion procedures, serving to restore physiological vertebral alignment and reestablish spinal stability. However, conventional fusion cages often face challenges related to insufficient osteointegration and the requirement for substantial bone grafting, which may result in incomplete fusion and prolonged recovery periods. In this study, we harnessed the osteointegration advantages of tantalum (Ta), in conjunction with advanced 3D printing technology, to develop a novel non-window-type Ta cage. The mechanical and biological characteristics of the cage were comprehensively evaluated through mechanical testing, in vitro cellular assays, and in vivo sheep anterior cervical discectomy and fusion models. The results indicated that the 3D-printed poro

SUBMITTER: Liang H 

PROVIDER: S-EPMC11889618 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature