Lymphoma-on-chip model reveals that lymph node stromal cells promote diffuse large B-cell lymphoma survival and migration.

ABSTRACT: Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive B-cell non-Hodgkin lymphoma, often developing resistance to current treatments. Development and testing of new therapies is hampered by lack of good in vivo and in vitro models mimicking human disease. Here, we developed a lymphoma-on-chip model to investigate the tumor-supportive roles of lymph node stromal cells (LNSCs) - fibroblastic reticular cells (FRCs) and lymphatic endothelial cells (LECs) - in the DLBCL microenvironment. The model includes a tubular vessel lined with LECs surrounded by a hydrogel with DLBCL cells and FRCs. Our findings reveal that FRCs promote DLBCL survival and facilitate tumor cell migration towards lymphatic vessels. Moreover, we demonstrate that DLBCL cells increase permeability

SUBMITTER: Jouybar M 

PROVIDER: S-EPMC11889632 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature