Functional neuroimaging of major depressive disorder: a meta-analysis and new integration of base line activation and neural response data.

ABSTRACT:

Objective

Functional neuroimaging investigations of major depressive disorder can advance both the neural theory and treatment of this debilitating illness. Inconsistency of neuroimaging findings and the use of region-of-interest approaches have hindered the development of a comprehensive, empirically informed neural model of major depression. In this context, the authors sought to identify reliable anomalies in baseline neural activity and neural response to affective stimuli in major depressive disorder.

Method

The authors applied voxel-wise, whole-brain meta-analysis to neuroimaging investigations comparing depressed to healthy comparison groups with respect to baseline neural activity or neural response to positively and/or negatively valenced stimuli.

Results

Rel

SUBMITTER: Hamilton JP 

PROVIDER: S-EPMC11889638 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature