Reward processing in healthy offspring of parents with bipolar disorder.

ABSTRACT:

Importance

Bipolar disorder (BD) is highly familial and characterized by deficits in reward processing. It is not known, however, whether these deficits precede illness onset or are a consequence of the disorder.

Objective

To determine whether anomalous neural processing of reward characterizes children at familial risk for BD in the absence of a personal history of a psychopathologic disorder.

Design, setting, and participants

This study compared neural activity and behaviors of children at high and low risk for mania while they anticipate and respond to reward and loss. The study was performed from September 15, 2009, through February 17, 2012, in a university functional magnetic resonance imaging facility and included 8- to 15-year-old children without disorders bo

SUBMITTER: Singh MK 

PROVIDER: S-EPMC11889639 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature