Sweet spot for resting-state functional MRI effect of deep brain stimulation in dystonia lies in the lower pallidal area.

ABSTRACT:

Introduction

Deep brain stimulation (DBS) of the internal globus pallidus (GPi) is a well-established, effective treatment for dystonia. Substantial variability of therapeutic success has been the one of the drivers of an ongoing debate about proper stimulation site and settings, with several indications of the notional sweet spot pointing to the lower GPi or even subpallidal area.

Methods

The presented patient-blinded, random-order study with cross-sectional verification against healthy controls enrolled 17 GPi DBS idiopathic, cervical or generalised dystonia patients to compare the effect of the stimulation in the upper and lower GPi area, with the focus on sensorimotor network connectivity and local activity measured using functional magnetic resonance.

Results

Sti

SUBMITTER: Filip P 

PROVIDER: S-EPMC11889665 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature