Chemotaxis of Drosophila border cells is modulated by tissue geometry through dispersion of chemoattractants.

ABSTRACT: Migratory cells respond to graded concentrations of diffusible chemoattractants in vitro, but how complex tissue geometries in vivo impact chemotaxis is poorly understood. To address this, we studied the Drosophila border cells. Live-imaged border cells varied in their chemotactic migration speeds, which correlated positionally with distinct architectures. We then developed a reduced mathematical model to determine how chemoattractant distribution is affected by tissue architecture. Larger extracellular volumes locally dampened the chemoattractant gradient and, when coupled with an agent-based motion of the cluster, reduced cell speeds. This suggests that chemoattractant levels vary by tissue architectures, informing cell migration behaviors locally, which we tested in viv

SUBMITTER: George A 

PROVIDER: S-EPMC11889670 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature