White matter microstructural integrity mediates associations between prenatal endocrine-disrupting chemicals exposure and intelligence in adolescents.

ABSTRACT: Per- and polyfluoroalkyl substances (PFAS) and phthalic acid esters (PAEs) are well-known endocrine-disrupting chemicals (EDCs) that potentially affect child neurodevelopment. We aimed to investigate the effects of prenatal exposure to PFAS and PAEs on macro- and micro-structural brain development and intelligence in adolescents using multimodal neuroimaging techniques. We employed structural magnetic resonance imaging (MRI) and various diffusion MRI techniques, including diffusion tensor imaging (DTI), diffusion kurtosis imaging (DKI), and neurite orientation dispersion and density imaging (NODDI), to assess the gray-matter macrostructure and white-matter microstructural integrity and complexity. Participants were drawn from a birth cohort of 52 mother-child pairs in central Taiwan recrui

SUBMITTER: Wang SM 

PROVIDER: S-EPMC11889738 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature