Relationship between BMI and chemotherapy-induced peripheral neuropathy in cancer patients: a dose-response meta-analysis.

ABSTRACT:

Objective

This meta-analysis aimed to evaluate the dose-response relationship between body mass index (BMI) and the risk of chemotherapy-induced peripheral neuropathy (CIPN) in cancer patients.

Methods

We conducted a dose-response meta-analysis of 10 studies involving 6,841 cancer patients. Studies reporting BMI and CIPN outcomes were selected. The relationship between BMI and CIPN was assessed using random-effects models and restricted cubic splines to model the dose-response association.

Results

Pooled analysis revealed a significant association between higher BMI and increased risk of CIPN, with an odds ratio (OR) of 1.55 (95% CI, 1.20-1.99). A dose-response analysis demonstrated a clear linear relationship between BMI and the risk of CIPN. For every 5 kg/m^2</

SUBMITTER: Yanbing L 

PROVIDER: S-EPMC11889769 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature