Post-transcriptional regulation in early cell fate commitment of germ layers.

ABSTRACT:

Background

Cell differentiation during development is orchestrated by precisely coordinated gene expression programs. While some regulatory mechanisms are well understood, there is a significant room to explore unresolved aspects of lineage choice and cell-fate decisions, as many events in these processes are still not fully elucidated. Given that, gene expression is influenced not only by transcriptional control but also by post-transcriptional events. Here, we described the presence of post-transcriptional regulation on gene expression during lineage commitment across all three embryonic germ layers. We employed monolayer differentiation protocols to map early transcriptional and post-transcriptional events in human embryonic stem cell specification. This approach included obtain

SUBMITTER: Gomes-Junior R 

PROVIDER: S-EPMC11889779 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature