Effect of methylprednisolone vs hydrocortisone on 30-day mortality in critically ill adults with septic shock: an analysis of the MIMIC-IV database.

ABSTRACT:

Background

Methylprednisolone is still used to treat adults with septic shock in real-world clinical settings, despite current international guidelines recommending hydrocortisone. The aim of this study was to assess the effect of methylprednisolone vs hydrocortisone on 30-day mortality among critically ill patients with septic shock.

Methods

We conducted a retrospective cohort study on adults with septic shock using the MIMIC-IV v3.0 database. Patients who received methylprednisolone after diagnosis were matched using propensity score matching (PSM) with those received hydrocortisone, to balance confounding factors between groups. The primary outcome was the 30-day mortality rate. Subgroup and sensitivity analyses were performed to assess the robustness of the conclusions.<

SUBMITTER: Xu J 

PROVIDER: S-EPMC11889804 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature