Plasma levels of adhesion molecules are elevated in dermatomyositis-interstitial lung disease and associated with low paraoxonase-1 activity.

ABSTRACT:

Objective

To evaluate circulating levels of intercellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) in patients with dermatomyositis (DM) and DM associated interstitial lung disease (DM-ILD).

Methods

We performed a cross-sectional study in plasma samples from DM patients and matched healthy controls. Plasma ICAM-1 and VCAM-1 (CAM) levels were measured by ELISA. The activity of paraoxonase-1 (PON1), a high density lipoprotein (HDL) associated antioxidative enzyme was measured using paraoxonase, arylesterase and lactonase assays. Association analysis was performed between clinical predictors and CAM levels. We analyzed whether CAM levels have a mediating role in the association between PON1 activity and IIM outcomes using causal mediation an

SUBMITTER: Bae SS 

PROVIDER: S-EPMC11889823 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature