Neuroinflammation causes mitral cell dysfunction and olfactory impairment in a multiple sclerosis model.

ABSTRACT:

Background

Olfactory dysfunction is an underestimated symptom in multiple sclerosis (MS). Here, we examined the pathogenic mechanisms underlying inflammation-induced dysfunction of the olfactory bulb using the animal model of MS, experimental autoimmune encephalomyelitis (EAE).

Results

Reduced olfactory function in EAE was associated with the degeneration of short-axon neurons, immature neurons, and both mitral and tufted cells, along with their synaptic interactions and axonal repertoire. To dissect the mechanisms underlying the susceptibility of mitral cells, the main projection neurons of the olfactory bulb, we profiled their responses to neuroinflammation by single-nucleus RNA sequencing followed by functional validation. Neuroinflammation resulted in the induction of po

SUBMITTER: Schubert C 

PROVIDER: S-EPMC11889885 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature