Serum IgE in the clinical features and disease outcomes of anti-interferon-γ autoantibodies syndrome.

ABSTRACT:

Background

Anti-interferon-γ autoantibodies (AIGAs) syndrome is a recently recognized adult-onset immunodeficiency syndrome. Serum Immunoglobulin E (IgE) is increased in AIGAs syndrome, but the role of serum IgE levels in the clinical features and disease outcomes of AIGAs syndrome is not clear.

Methods

We retrospectively enrolled 163 patients diagnosed AIGAs syndrome with serum IgE examined at baseline from 2021 to 2024 and compared the clinical features between Group A (serum IgE level ≤ 212 IU/mL) and Group B (serum IgE level > 212 IU/mL). Multivariable logistic regression method was used to explore the risk factors associated with disease outcomes.

Results

163 patients were included in this study, of whom 97 patients were in Group A (serum IgE level ≤ 212 IU/mL) a

SUBMITTER: Chen N 

PROVIDER: S-EPMC11889914 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature