Plant acetyl-CoA carboxylase: The homomeric form and the heteromeric form.

ABSTRACT: Across the domains of life, the enzyme acetyl-CoA carboxylase (ACC) converts HCO₃ ^-, ATP, and acetyl-CoA to malonyl-CoA, ADP, and P_i. Malonyl-CoA is the building block for all de novo fatty acid biosynthesis. ACC is found in two forms, (1) as a heteromeric enzyme, and (2) as a homomeric enzyme. Whether a single polypeptide, or various subunit combinations, they all catalyze the ATP-dependent carboxylation of acetyl-CoA to form malonyl-CoA. Here, we explore five burning questions pertaining to this fascinatingly intricate and complicated molecular machine, and the prospect of increasing oil production in plant vegetative tissues through its manipulation. We ask: 1. Can we manipulate the interplay of starch-lipid biosynthesis to increase the total TAG content

SUBMITTER: Niazi D 

PROVIDER: S-EPMC11889953 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature