Integrative analysis of genome-wide association studies of polyphenols in apple fruits identifies the MdDof2.4<i>-MdPAT10</i> module that promotes procyanidin accumulation.

ABSTRACT: Polyphenols represent a significant class of nutrients in apples, contributing to human health and well-being. Among these, procyanidins stand out as the most prevalent polyphenolic compounds in apple fruits. These compounds are abundant in wild apples and generally low in modern apple cultivars. Therefore, it is crucial to identify and recover genetically lost genes that regulate polyphenol accumulation in order to improve the apple quality. To achieve this, we conducted a genome-wide association study (GWAS) on 15 traits related to polyphenol content, utilizing 134 Malus accessions. We identified 1204 marker-trait associations (MTAs) and 840 candidate genes, including known polyphenol biosynthetic and regulatory genes, such as MYB7, TT4, and HCT/HQT. Notably,

SUBMITTER: Li Z 

PROVIDER: S-EPMC11890028 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature