Air pollution exposure in vitrified oocyte donors and male recipient partners in relation to fertilization and embryo quality.

ABSTRACT:

Background

Studies on air pollution and outcomes of in vitro fertilization (IVF) have focused on couples undergoing autologous IVF, in which it is challenging to disentangle maternal and paternal exposures during gametogenesis. We sought to evaluate the independent associations between air pollution exposure during oogenesis and spermatogenesis on fertilization and embryo quality in non-identified donor oocyte IVF cycles.

Methods

Our study included 500 oocyte donors and 915 male recipient partners who contributed 1,095 oocyte thaw cycles (2008-2019). Daily ambient air pollutant exposure was estimated using spatio-temporal models based on residential address and averaged over folliculogenesis (i.e., three months prior to initiation of controlled ovarian stimulation), controll

SUBMITTER: LaPointe S 

PROVIDER: S-EPMC11890188 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature