Beyond bone volume: Understanding tissue-level quality in healing of maxillary vs. femoral defects.

ABSTRACT: Currently, principles of tissue engineering and implantology are uniformly applied to all bone sites, disregarding inherent differences in collagen, mineral composition, and healing rates between craniofacial and long bones. These differences could potentially influence bone quality during the healing process. Evaluating bone quality during healing is crucial for understanding local mechanical properties in regeneration and implant osseointegration. However, site-specific changes in bone quality during healing remain poorly understood. In this study, we assessed newly formed bone quality in sub-critical defects in the maxilla and femur, while impairing collagen cross-linking using β-aminopropionitrile (BAPN). Our findings revealed that femoral healing bone exhibited a 73 % increase in bone

SUBMITTER: Romanowicz GE 

PROVIDER: S-EPMC11890190 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature