Limbic Intrinsic Connectivity in Depressed and High-Risk Youth.

ABSTRACT:

Objective

Depression runs in families and has been associated with dysfunctional limbic connectivity. Whether aberrant limbic connectivity is a risk factor for or a consequence of depression is unclear. To examine this question, we compared resting state functional connectivity (RSFC) in youth with depressive disorders (DEP), healthy offspring of parents with depression (DEP-risk), and healthy comparison (HC) youth.

Method

Magnetic resonance imaging at rest was acquired from 119 youth, aged 8 to 17 years (DEP, n = 41, DEP-risk, n = 39, and HC, n = 39) and analyzed using seed-based RSFC in bilateral amygdala and nucleus accumbens (NAcc), covarying for age, IQ, and sex.

Results

We found distinct risk- and disorder-specific patterns of RSFC across groups. DEP-risk and DE

SUBMITTER: Singh MK 

PROVIDER: S-EPMC11890206 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature