Poly ADP-ribosylation regulates Arc expression and promotes adaptive stress-coping.

ABSTRACT:

Rationale

Rapid adaptation to stressful events is essential for survival and requires acute stress response and stress-coping strategy. However, the molecular mechanisms that govern this coping strategy have yet to be fully discovered.

Objectives

This study aims to investigate the effects of poly ADP-ribosylation (PARylation) on stress-coping strategies following acute stress and to identify the target genes influenced by Parp1-induced histone PARylation.

Methods

Mice were subjected to a forced swim test, a well-established acute stress paradigm, to evaluate cortical PARylation and assess the expression of activity-dependent genes. The pharmacological inhibition of Parp1 was conducted using ABT888 (Veliparib) to determine its effects on stress-coping behavior and rela

SUBMITTER: Dahan E 

PROVIDER: S-EPMC11890342 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature