Value signals guiding choices for cannabis versus non-drug rewards in people who use cannabis near-daily.

ABSTRACT:

Rationale

Despite the critical role of choice processes in substance use disorders, the neurobehavioral mechanisms guiding human decisions about drugs remain poorly understood.

Objectives

We aimed to characterize the neural encoding of subjective value (SV) for cannabis versus non-drug rewards (snacks) in people who use cannabis on a near-daily/daily frequency (PWUCF) and assessed the impact of cannabis and snack stimuli ('cues') on SV encoding.

Methods

Twenty-one non-treatment-seeking PWUCF (≥4 days/week; 1 female) participated in an inpatient, crossover experiment with four counterbalanced conditions: 1. neutral cues/cannabis choices; 2. cannabis cues/cannabis choices; 3. neutral cues/snack choices; and 4. snack cues/snack choices. In each condition, participants we

SUBMITTER: Lawn W 

PROVIDER: S-EPMC11890362 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature