PeiTuQingXin formula alleviated atopic dermatitis symptoms via inhibiting TRADD/TRAF2/RIP1 complex mediated NF-κB signaling pathway activation.

ABSTRACT: Atopic dermatitis (AD) is a chronic inflammatory skin disease with recurrent course, and traditional Chinese medicine (TCM) is regarded as an effective treatment. In this study, we aim to evaluate the potential effects and elucidate the mechanism of PTQX formula in alleviating a house dust mite (HDM)-induced AD model. NC/Nga mice were divided into Control, AD model and PTQX-treated and stimulated with HDM oinment. PTQX formula exerted significant anti-inflammatory effects, alleviated dermatitis performance, decreased the serum IgE by more than 2-fold, reduced the secretion level of other inflammatory cytokines and downregulated the Th2 cells ratio in lymph nodes. Treatment with PTQX formula reduced the level of inflammatory cytokines, which was measured by an inflammatory cytokine array ki

SUBMITTER: Cheng Z 

PROVIDER: S-EPMC11890400 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature