Systemic immune inflammation mediates the association of serum omega-3 and omega-6 polyunsaturated fatty acids with biological aging: a national population-based study.

ABSTRACT:

Objective

This study aimed to explore the association between serum omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) and biological aging, along with the potential mediating role of systemic immune inflammation (SII).

Methods

Data from the National Health and Nutrition Examination Survey (NHANES) 2011-2014 were used for analyses. Accelerated aging in participants was assessed by calculating the difference between phenotypic age (PhenoAge) and chronological age. Weighted multivariate linear regression models and subgroup analysis were used to investigate the correlation between serum n-3 and n-6 PUFAs and accelerated aging, and restricted cubic spline (RCS) model was applied to explore potential nonlinear relationships. We further conducted mediation analys

SUBMITTER: Shan F 

PROVIDER: S-EPMC11890405 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature