Glutathione alterations in depression: a meta-analysis and systematic review of proton magnetic resonance spectroscopy studies.

ABSTRACT:

Background

Major depressive disorder (MDD) is a common and serious psychiatric disorder associated with significant morbidity. There is mounting evidence for the role of oxidative stress in the pathophysiology of depression.

Objective

To investigate alterations in the brain antioxidant glutathione in depression by undertaking a meta-analysis of proton magnetic resonance spectroscopy (1H-MRS).

Methods

MEDLINE, EMBASE and Psych Info databases were searched for case-control studies that reported brain glutathione levels in patients with depression and healthy controls. Means and variances (SDS) were extracted for each measure to calculate effect sizes. Hedges g was used to quantify mean differences. The Meta-analysis of Observational Studies in Epidemiology (MOOSE) and P

SUBMITTER: Bell CJM 

PROVIDER: S-EPMC11890406 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature