Global, regional and national burden of liver cancer 1990-2021: a systematic analysis of the global burden of disease study 2021.

ABSTRACT:

Background

Liver cancer is a growing global health issue, with significant geographical disparities in prevalence and mortality. Understanding these differences is key to developing effective prevention and treatment strategies.

Methods

We analyzed liver cancer trends from 1990 to 2021 across 204 countries using data from the Global Burden of Disease (GBD) study. We modeled mortality from vital registration data and estimated non-fatal burden using primary studies, hospital discharges, and claims data. We calculated prevalence, mortality, YLLs, YLDs, and DALYs, adjusting for age and reporting rates per 100,000 population with 95% UI.

Findings

In 2021, there were 739,299 (673114-821948) cases of liver cancer worldwide. The age-standardized prevalence rate increased fro

SUBMITTER: Jiang Z 

PROVIDER: S-EPMC11890516 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature