Effect of N-acetylcysteine on antimicrobials induced nephrotoxicity: a meta-analysis.

ABSTRACT:

Objective

N-acetylcysteine (NAC) has antioxidant effects in reducing acute kidney injury. This study systematically reviewed and assessed the efficacy of NAC in preventing antimicrobials induced nephrotoxicity.

Methods

Pubmed, Embase, Web of Science, and the Cochrane Library were searched extensively for relevant studies that evaluating NAC on antimicrobials induced nephrotoxicity until June 1, 2024. Eligible records were screened according to the inclusion and exclusion criteria. The odds ratio (OR) was selected to evaluate the effect of NAC on nephrotoxicity. We pooled the extracted data using a random effects model.

Results

Three randomized controlled trials were included in the analysis. The pooled results showed that NAC could reduce the incidence of antimicrobia

SUBMITTER: Qiu X 

PROVIDER: S-EPMC11890532 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature