Stability-indicating spectrophotometric manipulations for the determination of Letrozole in the presence of its alkali-induced degradation products; towards whiteness and ChlorTox scale perspectives.

ABSTRACT: Letrozole (LTZ) is an established first hormonal treatment for breast cancer, yet it was found to be highly susceptible for degradation in alkaline medium due to the presence of cyano phenyl group. Consequently, three stability-indicating spectrophotometric manipulations for LTZ quantification in presence of its alkali-induced degradation products were developed for the first time; ensuring methods' simplicity, sensitivity and accuracy. The first method was Second derivative (D₂) by recording peak amplitude of the drug at 226.8 nm. The second method was Ratio difference (RD) where the peak amplitude were recorded at wavelengths 240.0 nm and 258.0 nm. The third method was First derivative of ratio spectra (DD₁) through recording peak amplitude at 246.0 nm. Linearity ra

SUBMITTER: El-Fatah NAA 

PROVIDER: S-EPMC11890550 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature