Net albumin leakage in patients in the ICU with suspected sepsis. A prospective analysis using mass balance calculations.

ABSTRACT:

Introduction

Albumin kinetics in septic shock have been extensively studied, but clinical recommendations remain weak. An increased transcapillary escape rate (TER) of albumin has been demonstrated, though TER does not account for lymphatic return. Mass balance calculations, considering lymphatic return, have been used to assess net albumin leakage (NAL) in major surgery but not in sepsis.

Objectives

This study aimed to evaluate NAL in ten ICU patients with suspected sepsis, hypothesizing a net positive leakage. Secondary aims included investigating associations between NAL and fluid overload, glycocalyx shedding products, and cytokines, as well as identifying factors associated with it.

Methods

This prospective, observational study included ten patients within twelve

SUBMITTER: Selden D 

PROVIDER: S-EPMC11890723 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature