Cellular and extracellular matrix aspects of the nasal cartilage in the fetus and early infant.

ABSTRACT: A comprehensive description of nasal septal cartilage (NSC) across all age groups is an unmet need. This information could help improve facial reconstruction, particularly in childhood. We describe cellular distribution and metabolic activity in the NSC of fetus, newborn, and 2-year-old infants using postmortem samples. Cell density in 9 NSC areas and isogenous groups/hpf were counted on hematoxylin-eosin-stained sections. The production of glycosaminoglycans, measured using Safranin O staining, was used as a surrogate for metabolic activity. 12 samples from 5, 4 and 3 fetuses, newborns, and early infants, respectively, were evaluated, 7 (57.8%) of which were male with a median age of 0.5 days. Cell density and isogenous groups were significantly higher (p < 0.05) in the anterior two-third

SUBMITTER: Borsaro R 

PROVIDER: S-EPMC11890739 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature