Reduced removal of waste products from energy metabolism takes center stage in human brain aging.

ABSTRACT: Despite extensive research on neuroimaging correlates of human brain aging, there is little mechanistic insight into how they are linked to loss of brain function. Previous studies on the role of cerebral blood flow (CBF) in supporting brain function have focused on delivery of nutrients, namely oxygen and glucose. However, CBF is required also to clear the byproducts of energy metabolism, namely CO₂ and protons. With the goal of determining whether age-associated reduction in regional CBF may lead to abnormal brain partial pressure of carbon dioxide (pCO₂) and pH levels that are sufficient to alter brain activity and cognitive function, we applied a recently introduced homeostatic modeling of nutrients and waste products to human neuroimaging PET data acquired in you

SUBMITTER: Mangia S 

PROVIDER: S-EPMC11890754 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature