Novel function of TREK-1 in regulating adipocyte differentiation and lipid accumulation.

ABSTRACT: K2P (two-pore domain potassium) channels, a diversified class of K⁺-selective ion channels, have been found to affect a wide range of physiological processes in the body. Despite their established significance in regulating proliferation and differentiation in multiple cell types, K2P channels' specific role in adipogenic differentiation (adipogenesis) remains poorly understood. In this study, we investigated the engagement of K2P channels, specifically KCNK2 (also known as TREK-1), in adipogenesis using primary cultured adipocytes and TREK-1 knockout (KO) mice. Our findings showed that TREK-1 expression in adipocytes decreases substantially during adipogenesis. This typically causes an increased Ca²⁺ influx and alters the electrical potential of the cell membrane in

SUBMITTER: Kim A 

PROVIDER: S-EPMC11890776 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature