C(sp³)-heteroatom bond formation by iron-catalyzed soft couplings.

ABSTRACT: Carbon-heteroatom bonds are of great importance due to their prevalence in pharmaceuticals, agrochemicals, materials, and natural products. Despite the effective use of metal-catalyzed cross-coupling reactions between sp²-hybridized organohalides and soft heteroatomic nucleophiles for carbon-heteroatom bond formation, the use of sp³-hybridized organohalides remain limited and the coupling with thiols remains elusive. Here, we report the coupling of sp³-hybridized benzyl or tertiary halides with soft thiol nucleophiles catalyzed by iron and extend the utility to alcohol and amine nucleophiles. The reaction is broad in substrate scope for both coupling partners and applicable in the construction of congested tri- and tetrasubstituted carbon centers as well as

SUBMITTER: Semenya J 

PROVIDER: S-EPMC11890871 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature