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Stress responses induced by perturbation of the ubiquitin-proteasome system.

ABSTRACT: The ubiquitin-proteasome system is key for proteostasis and its disruption can induce several cellular adaptations. Here, we summarize the range of cellular responses that are induced by perturbation of distinct components of the ubiquitin-proteasome system, and how proteasome stress in a tissue can induce systemic responses in distant tissues.

SUBMITTER: Rai M 

PROVIDER: S-EPMC11890940 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature

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Stress responses induced by perturbation of the ubiquitin-proteasome system.

Rai Mamta M   Hunt Liam C LC   Demontis Fabio F  

Trends in biochemical sciences 20250107 3

The ubiquitin-proteasome system is key for proteostasis and its disruption can induce several cellular adaptations. Here, we summarize the range of cellular responses that are induced by perturbation of distinct components of the ubiquitin-proteasome system, and how proteasome stress in a tissue can induce systemic responses in distant tissues. ...[more]

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