Neural Correlates and Adaptive Mechanisms in Vascular Cognitive Impairment: Exploration of a Structure-Function Coupling Network.

ABSTRACT:

Background

Cerebral small vessel disease exacerbates cognitive decline, yet the structural-functional coupling mechanisms in vascular cognitive impairment (VCI) remain unclear.

Methods

This study included 121 participants, with 68 individuals with VCI and 53 healthy controls. Participants underwent neuropsychological assessments and multimodal imaging. We compared white matter integrity, structural network topology, and functional network topology between groups, exploring the relationship between structure-function coupling and cognitive function. Family-wise error (FWE) correction was applied to account for multiple comparisons.

Results

VCI participants showed reduced fractional anisotropy and increased mean and radial diffusivity in white matter. Structural network

SUBMITTER: Jin J 

PROVIDER: S-EPMC11890977 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature