Case Report: A case series on histiocytic sarcoma - various clinical features and patient outcomes.

ABSTRACT:

Introduction

Histiocytic sarcoma (HS) is a rare and aggressive hematologic malignancy with a poor prognosis. HS can present with either isolated organ involvement or multi-systemic disease. This case series reports on nine patients with diverse clinical presentations and outcomes.

Methods

Diagnoses of HS were confirmed using immunohistochemistry, with markers such as CD68 and lysozyme. Treatment primarily involved anthracycline-based chemotherapy with autologous hematopoietic stem cell transplantation (auto-HSCT) consolidation, and with salvage therapies for resistant or relapsed cases including allogeneic HSCT (allo-HSCT).

Results

Despite intensive treatment, long-term remission was rare. Among the nine patients, three achieved complete remission but relapsed, three

SUBMITTER: Nam H 

PROVIDER: S-EPMC11891036 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature