Biochemical remission, diagnostic delays, and comorbidities of acromegaly in China: a large single-centre retrospective study.

ABSTRACT:

Introduction

Long-term biochemical nonremission and long-delayed diagnosis can increase the incidence of comorbidities of acromegaly and seriously affect patients' quality of life. To identify predictors of biochemical remission and quantify the relationship between delayed diagnosis and comorbidities, we performed a retrospective study of a large, single-centre cohort.

Methods

This retrospective cohort included 1692 hospitalised patients with acromegaly seen in a single referral centre between 2012 and 2020. To account for the longitudinal data structure, generalised estimating equation (GEE) regression models were established to further evaluate the factors associated with biochemical remission.

Results

Overall, 1692 inpatients (55.4% females, mean age at diagnosis:

SUBMITTER: Bai X 

PROVIDER: S-EPMC11891042 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature