Potential of transcranial ultrasound- and near-infrared spectroscopy-based acute stroke imaging for decision-making on intravenous thrombolysis treatment.

ABSTRACT:

Background

Mobile Stroke Units (MSU) shorten time to intravenous thrombolysis (IVT) and improve functional outcome, but they rely on computed tomography (CT) making them highly specialized and costly. Alternative technologies can potentially identify imaging-based IVT contraindications like intracranial hemorrhage (ICH) or malignancies (IM), e.g., by transcranial color-coded sonography (TCCS) and near-infrared spectroscopy (NIRS).

Methods

Using a simulation approach, we analyzed magnetic resonance imaging (MRI) scans of stroke-suspected patients within 4.5 h of symptom onset to assess TCCS and NIRS for identifying imaging-based IVT contraindications. Our study included both primary and sensitivity analyses, each employing conservative and optimistic scenarios. The primary an

SUBMITTER: Freitag E 

PROVIDER: S-EPMC11891060 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature