Multivariate Association Between Functional Connectivity Gradients and Cognition in Schizophrenia Spectrum Disorders.

ABSTRACT:

Background

Schizophrenia spectrum disorders (SSDs), which are characterized by social cognitive deficits, have been associated with dysconnectivity in unimodal (e.g., visual, auditory) and multimodal (e.g., default mode and frontoparietal) cortical networks. However, little is known about how such dysconnectivity is related to social and nonsocial cognition and how such brain-behavior relationships associate with clinical outcomes of SSDs.

Methods

We analyzed cognitive (nonsocial and social) measures and resting-state functional magnetic resonance imaging data from the SPINS [Social Processes Initiative in Neurobiology of the Schizophrenia(s)] study (247 stable participants with SSDs and 172 healthy control participants, ages 18-55 years). We extracted gradients from parcell

SUBMITTER: Yu JC 

PROVIDER: S-EPMC11891086 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature