Mobile genetic elements encoding antibiotic resistance genes and virulence genes in <i>Klebsiella pneumoniae</i>: important pathways for the acquisition of virulence and resistance.

ABSTRACT: Klebsiella pneumoniae is an opportunistic pathogen primarily associated with nosocomial infections, characterized by a propensity for multi-drug resistance and the potential evolution into hypervirulent strains. Based on its phenotypic and genotypic characteristics, K. pneumoniae can be classified into two types: classical K. pneumoniae (cKP) and hypervirulent K. pneumoniae (hvKP). The spread of mobile genetic elements (MGEs) in K. pneumoniae has led to the emergence of carbapenem-resistant K. pneumoniae (CRKP) and carbapenem-resistant hypervirulent K. pneumoniae (CR-hvKP). The emergence of CR-hvKP is particularly concerning due to its multidrug resistance, high pathogenicity, and increased transmissibility. This review summarizes the types

SUBMITTER: Han B 

PROVIDER: S-EPMC11891212 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature