Association between serum oxidative stress indicators, inflammatory indicators and suicide attempts in adolescents with major depressive disorder.

ABSTRACT:

Background

Progress in research on the neurobiology of suicide behavior in adolescents has notably lagged compared to that of adults. This study aimed to investigate the associations between serum indicators, including oxidative stress (OS) and inflammatory indicators, and psychological factors with suicide attempts (SA) in adolescents with major depressive disorder (MDD) while also exploring potential markers.

Methods

This study involved the psychological assessment of 106 first-time hospitalized adolescents aged 12 to 18 with MDD and the measurement of serum indicators. Participants were categorized into two groups according to their history of SA within the preceding six months. Screening the best markers for suicide by machine learning algorithms. Multivariable logistic

SUBMITTER: Peng C 

PROVIDER: S-EPMC11891218 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature