Association between estimated glucose disposal rate and incident cardiovascular disease in a population with Cardiovascular-Kidney-Metabolic syndrome stages 0-3: insights from CHARLS.

ABSTRACT:

Objective

Estimated glucose disposal rate (eGDR) is a reliable marker of insulin resistance (IR), which has been proven to be strongly linked to cardiovascular and renal diseases. However, the link between eGDR and the occurrence of cardiovascular disease (CVD) in individuals exhibiting Cardiovascular-Kidney-Metabolic (CKM) syndrome stages 0-3 remains ambiguous.

Methods

The data employed in this investigation was procured from the China Health and Retirement Longitudinal Study (CHARLS). The outcome of this study was CVD events, which include heart disease and stroke. Cox regression models and restricted cubic spline (RCS) were employed to investigate the association between eGDR and CVD risk among individuals with CKM syndrome stages 0-3.

Results

This investigation en

SUBMITTER: Tan Z 

PROVIDER: S-EPMC11891229 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature