Neutrophil extracellular traps and macrophage activation contibute to thrombosis and post-covid syndrome in SARS-CoV-2 infection.

ABSTRACT:

Background

SARS-CoV-2 infection activates macrophages and induces the release of neutrophil extracellular traps (NETs). Excess NETs is linked to inflammatory and thrombotic complications observed in COVID-19.

Aim

To explore the impact of NETs and macrophage activation on SARS-CoV-2-infected patients who developed complications.

Methods

We included 30 patients from the first (March 2020) and 30 from the second wave (July 2021), collecting two plasma samples at diagnosis and seven days later. Data on demographics, comorbidities, and basic analytical data were compiled. NETs markers (myeloperoxidase (MPO), neutrophil elastase (NE), p-selectin (P-SEL) and S100A8/S100A9 heterodimer (MRP)) and macrophage activation markers (Chitotriosidase activity (ChT), CCL18/PARC and YKL

SUBMITTER: Serrano-Gonzalo I 

PROVIDER: S-EPMC11891236 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature