Elucidating the role of KCTD10 in coronary atherosclerosis: Harnessing bioinformatics and machine learning to advance understanding.

ABSTRACT: Atherosclerosis (AS) is increasingly recognized as a chronic inflammatory disease that significantly compromises vascular health and serves as a major contributor to cardiovascular diseases. KCTD10, a protein implicated in a variety of biological processes, has garnered significant attention for its role in cardiovascular diseases and metabolic regulation. As a member of the KCTD protein family, KCTD10 is characterized by the presence of a T1 domain that interacts with voltage-gated potassium channels, a critical interaction for modulating channel activity and intracellular signal transduction. In our study, KCTD10 was identified as a focal point through an integrative analysis of differentially expressed genes (DEGs) across multiple datasets (GSE43292 and GSE9820) from the GEO database, a

SUBMITTER: Hu X 

PROVIDER: S-EPMC11891306 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature