The marine xanthophyll diatoxanthin as ferroptosis inducer in MDAMB231 breast cancer cells.

ABSTRACT: Marine biotopes are considered as a huge reservoir of biodiversity and chemodiversity, the latter potentially providing new treats for health prevention. Among the emphasized marine biocenosis, microorganisms such as microalgae propose suitable solutions to address eco-sustainability or biorefinery topics. The health interests of the xanthophyll diatoxanthin (Dt), a photoprotective and antioxidant pigment synthetized by diatoms, have been recently documented. This study deeply explores the capacity of Dt to intercept cancer progression and addresses the Dt -induced cell death in breast cancer. It is crucial to know which signalling pathway explaining its function is induced by the molecule in the targeted cells. This study disentangled the intracellular effects of Dt in MDAMB231 breast can

SUBMITTER: Sansone C 

PROVIDER: S-EPMC11891320 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature